Scientists identify cause of Botticelli’s model’s death
lemonde.fr · 19 October 2026

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Scientists in Italy determined that Simonetta Vespucci, a famous model for the Florentine artist Sandro Botticelli, did not die from tuberculosis, as historians previously believed.
Researchers examined Botticelli’s paintings of Vespucci and reached a new diagnosis regarding the cause of her death at age 23. The team based their findings on details visible in the artwork, offering a revised understanding of a mystery that has persisted for over five centuries.
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